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Diarrhea: Diarrhea is a typical side effect, in some cases critical sufficient to require dosage adjustment or supplemental drugs.duvelisib will boost the level or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration with duvelisib increases AUC of the sensitive CYP3A4 subs